Association between XRCC1 Arg399Gln, Arg280His, Arg194Trp polymorphisms and cervical cancer risk: a pooled analysis based on Chinese individuals

Although various individual studies have evaluated the correlation between X-ray repair cross-complementing group 1 (XRCC1) polymorphisms and cervical cancer, the current results remain inconclusive. Therefore, we performed a pooled analysis based on Chinese individuals to provide comprehensive data on the association between XRCC1 Arg399Gln, Arg194Trp, Arg280His polymorphisms and cervical cancer risk. Studies were identified using PubMed and Chinese databases through July 2016. A total of ten studies with 2049 cervical cancer cases and 2922 controls were included in this meta-analysis. It revealed that XRCC1 Arg399Gln and Arg194Trp polymorphisms were significantly associated with an increased risk of cervical cancer in our study. No significant association was observed between XRCC1 Arg280His and cervical cancer in all the models. In conclusion, this metaanalysis suggests that XRCC1 Arg399Gln and Arg194Trp polymorphisms may be associated with cervical cancer risk in Chinese individuals, while Arg280His polymorphism might not be a risk factor for cervical cancer.